Practice of Epidemiology The Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM): Methods, Design, and Sample Characteristics

ion Survey of body changes in the last 5 years Visual inspection of body sites Magnetic resonance imaging Blood All current medications Cheeks, face, neck, breasts, chest, upper back, waist, hips, buttocks, arms and legs, and veins Cheeks, face, neck, chest, upper back, waist, abdominal fat, buttocks, thighs, arms, veins, and limb muscles Whole body HIV RNA levely Past medications Dual energy x-ray absorptiometry CD4 cell count, CD8 cell county Antiretroviral agents Body compositionz Fasting lipid panel (apolipoprotein B, high density lipoprotein cholesterol, calculated and directly measured low density lipoprotein cholesterol, total cholesterol, triglycerides) Anabolic agents Bone mineral density§ Hypoglycemic agents Medication history Height and weight measurement Hypolipidemic agents Antihypertensive agents Antiretroviral agents Anthropometric data Anabolic agents Elbow breadth Nuclear magnetic resonance expanded lipid analysis as part of fat tolerance test§ Hypoglycemic agents Skinfolds (tricepz, midthighz, abdominalz, subscapular§) Carotid ultrasonography§ Fasting glucose level{ Hypolipidemic agents Circumferences (neck, waist, hip, midthigh, chest§) Fasting insulin level{ Antihypertensive agents Lipomasz Inflammatory markers HIV-related illnesses Survey of HIV risk factors Blood pressure measurement Adipokines History (past 5 years) Sociodemographic factors Liver function tests CD4 and CD8 cell counts Medical and health history Hepatitis B and C serologyz HIV RNA level HIV-related illnesses Hepatitis C virus RNA levelz Weight Obstetric and gynecologic data (women only) Chemistry panel Nadir of CD4 cell county,z